In a month-old post at Pimp My Novel Eric predicts, not the death of the printed book altogether, but specific formats. One is the large-print book, the other is traditional audio books. Eric foresees the large-print book being replaced by e-readers because users can control the fonts on those, anyway, so there would be no reason to seek out a book just because it has large print. Audio books on CDs would be replaced by downloads, just as audio books on cassette tapes have been replaced by CDs.
Both predictions make sense to me, though I think there will be pockets of resistance to the loss of large-print books among older people who refuse to embrace technology (a group that is probably becoming smaller even as I type this) or romanticize the concept of paper books.